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September 10, 2025eJHaemOpen Access

Alpha‐Globin Gene Triplication in Central Thailand: Prevalence, Haematological Findings and Clinical Impact With Co‐Inherited Beta‐Globin Mutations

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Authors

BCBoonyanuch ChutvanichkulYCYingyong ChinthammitrTRTheera Ruchutrakool

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Overview

Retrospective analysis reveals alpha-globin triplication prevalence and its impact on haemoglobin levels in patients with beta-globin mutations.

Key Points

  • Alpha-globin triplication prevalence was found to be 1.28% among 1559 subjects in central Thailand, indicating its clinical relevance.
  • Carriers of alpha-globin triplications had mean haemoglobin levels lower than non-carriers, with significant drops noted in individuals with co-inherited beta-globin mutations.
  • The analysis was a retrospective review of clinical samples submitted for polymerase chain reaction-based alpha-globin mutation analysis at Siriraj Hospital from 2012 to 2021.
  • Finding suggests the need for routine screening for alpha-globin triplications to manage anemia in symptomatic individuals effectively.

Cite This Study

Chutvanichkul et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5ef54b1d3bfb60f8c04https://doi.org/10.1002/jha2.70128
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