Intracardiac hemodynamic parameters in male patients with essential hypertension carrying polymorphic variants of the cardiotrophin-1 gene

The aim – improvement of diagnosing the intracardiac and systemic hemodynamic changes in male left ventricular hypertrophy (LVH) patients with underlying essential hypertension (EH) being carriers of polymorphic variants of the corresponding coding gene (rs8046707) using the cardiotrophin-1 (CT-1) biomarker.Materials and methods. The study involved 70 male individuals without signs of cardiovascular pathology and LVH of other etiology, aged 48.81±0.78 years, and 50 male LVH patients with underlying EH without signs of chronic heart failure, aged 50.62±0.73 years. All study participants underwent a standard echocardiographic examination, blood serum CT-1 concentration enzyme-linked immunosorbent assay (ELISA), and CT-1 gene polymorphism (rs8046707) test of venous blood samples by polymerase chain reaction. Results. The CT-1 blood serum concentration in GG-genotype individuals without signs of cardiovascular pathology (n=31) was found to be lower than that in carriers of GA + AA genotypes (n=39), being equaled to 55.77±2.53 pg/ml and 92.46±1.54 pg/ml, respectively (p<0.001). The CT-1 blood plasma concentration in LVH subjects was significantly higher than in the control group patients, equaling 188.22±7.95 pg/ml and 282.33±11.52 pg/ml in GG males (n=22) and in GA + AA genotype carriers (n=28), respectively (p<0.001). The Spearman rank correlation method was used to establish a correlation between blood plasma CT-1 concentration and echocardiography readings.Conclusions. Stage II EH patients being carriers of CT-1 gene GA + AA genotypes demonstrated higher blood plasma CT-1 concentrations and correlation with echocardiography indicators. This fact suggests that changes in wall thickness and myocardial mass of EH II patients can be diagnosed using the above-mentioned marker as an additional ascertaining indicator.