Key result
Cardiotrophin-1 GA+AA variant linked to ~15% higher plasma cardiotrophin-1 levels in hypertensive HF.
Why the study?
Early diagnosis of myocardial diastolic dysfunction in men with essential hypertension and chronic heart failure is important but challenging, and the role of cardiotrophin-1 gene variants as biomarkers needed evaluation.
Observational (n=100)
Annotation. The aim of the study was to improve the diagnosis of myocardial diastolic function in men with essential hypertension and chronic heart failure with different variants of the cardiotrophin-1 gene. 100 people aged 40–60 were examined: 50 men with asymptomatic essential hypertension and 50 men with essential hypertension complicated by chronic heart failure. Genotyping of the cardiotrophin-1 gene was performed by polymerase chain reaction. Determination of the concentration of cardiotrophin-1 was performed by enzyme-linked immunosorbent assay. Structural and functional parameters of the myocardium were evaluated using ultrasound of the heart. Mathematical processing of the material was performed on a personal computer using the standard statistical package SPSS 10. It was found that in persons with essential hypertension and chronic heart failure, carriers of the GA + AA variant of the cardiotrophin-1 gene (rs8046707) have significantly higher plasma peptide levels with diastolic dysfunction (p <0.05).
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Matokhniuk et al. (2020) conducted an observational in Essential hypertension with and without chronic heart failure (n=100). GA+AA genotype of the cardiotrophin-1 gene (rs8046707) vs. GG genotype of the cardiotrophin-1 gene was evaluated on Plasma cardiotrophin-1 concentration (pg/ml) in patients with heart failure and diastolic dysfunction (p=<0.05). In men with essential hypertension and chronic heart failure, carriers of the GA+AA variant of the cardiotrophin-1 gene had significantly higher plasma cardiotrophin-1 levels compared to GG homozygotes.
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