Key result
Plasma cardiotrophin-1 levels were significantly higher in HCM patients than controls (P<0.001) and correlated with maximal left ventricular wall thickness (r=0.284, P=0.001).
Why the study?
Are plasma Cardiotrophin-1 (CT-1) levels associated with the severity of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy?
Observational (n=124)
Are plasma Cardiotrophin-1 (CT-1) levels associated with the severity of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy?
Effect estimate: r = 0.284
p-value: p=0.001
Plasma CT-1 levels are significantly elevated in patients with hypertrophic cardiomyopathy and correlate with the severity of left ventricular hypertrophy.
No takes yet. Share an insight, caveat, or question.
Elevated CT-1 associates with greater LV wall thickness in HCM; hypothesis-generating for biomarker role and should not yet change practice.
Monserrat et al. (2010) conducted an observational in Hypertrophic cardiomyopathy (n=124). Plasma Cardiotrophin-1 (CT-1) levels vs. Controls was evaluated on Correlation between CT-1 and maximal LV wall thickness (r = 0.284, p=0.001). Plasma cardiotrophin-1 levels were significantly higher in HCM patients than controls (P<0.001) and correlated with maximal left ventricular wall thickness (r=0.284, P=0.001).
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