Observational analysis linked a cVDPV1 outbreak to acute flaccid polio in Israel, highlighting the role of advanced sequencing and environmental surveillance.
We report the emergence and evolution of a circulating vaccine-derived poliovirus type 1 (cVDPV1) outbreak in Israel, linked to a vaccine-associated paralytic poliomyelitis case. Whole genome sequencing revealed a strong genetic link between the Sabin-like poliovirus type 1 variant from the case and pre-VDPV1 and VDPV1 isolated from environmental samples collected in October 2024-April 2025, mostly in Jerusalem. Early detection was made possible by Israel's robust environmental surveillance and advanced sequencing technologies, enabling a rapid public health response.
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Zuckerman et al. (2025) studied this question.
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