Key result
Routine wastewater surveillance in the Jerusalem region between April and July 2022 detected the emergence and genetic linkage of vaccine-derived poliovirus type 2.
Observational
Routine wastewater surveillance detected the emergence and potential circulation of type 2 vaccine-derived poliovirus in a high-income country with high vaccine coverage.
Documents VDPV2 emergence via wastewater in high-coverage Israel; leaves open optimal surveillance and response thresholds.
We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.
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Zuckerman et al. (2022) conducted an observational in Poliovirus type 2 emergence. Routine wastewater surveillance was evaluated on Detection of poliovirus type 2 and genetic linkage. Routine wastewater surveillance in the Jerusalem region between April and July 2022 detected the emergence and genetic linkage of vaccine-derived poliovirus type 2.
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