Intelligible Intelligence of Immune Neuroplasticity: Influence of Drugs and Vaccines on Mitochondria and Genomic Stability in Disease Processes

Background-Aim. Efforts to understand the intricate molecular and electrochemical dynamics of immune neuroplasticity, which safeguard health, have highlighted a significant public health shift in 20th century toward induced diseases. In the United States, prevalence of cancers, autoimmune and neurodegenerative illnesses rose dramatically, reaching rates of 50-80%, for younger and older populations, compared to the much lower rates of 1-5% for congenital or inherited conditions in last century. After the 1986 National Childhood Vaccine Injury Act (NCVIA) granted vaccine manufacturers immunity from liability, vaccine promotion surged, particularly targeting fetuses, newborns, and immunocompromised individuals. This perspective suggests that the rise in induced diseases to be closely tied to significant increase in childhood vaccination. Material-Methods. Human birth is viewed as a continuation of fetal development outside the womb, marked by a state of vulnerability or ‘helplessness’. During first two years of life, as newborn is exposed to atmospheric oxygen, body's organs and immune system, including mitochondria, continue completing their development. Defence mechanisms, governed by biological rhythms, require differential bioenergetic for ATP production from mitochondria and cytoplasm to maintain health. An effective immune system balances tumoricidal (Yin, apoptosis, degeneration) and tumorigenic (Yang, wound healing, regeneration) processes, characterized by self-limiting and protective nature of acute inflammation. Validity of heavily focusing on genetics or ‘heredity’ as origin of diseases (eg, cancers, autoimmune, and neurodegenerative disorders) is also being challenged. Results. Autonomic and intelligible intelligence of immune neuroplasticity can be affected, weakened, or damaged by both external and internal factors. These include repeated infections, genotoxins, low-level carcinogens, defective cells or proteins, high-energy electronic devices (wearables), aging, substance abuse, or pathogen-specific vaccines and ingredients or synthetic-engineered and modified mRNA-DNA spike proteins encased in lipid nanoparticles. Conclusions: Over-vaccination of unborn babies, newborns, infants, or those with compromised immunity might disrupt immune neuroplasticity, harm mitochondrial and histamine functions, and activate genes that could lead to abnormal expression and co-expression of receptors, surface molecules, metabolites or mediators. Imbalanced tissue bioenergetics and immune responses likely trigger or worsen diseases. Permanent loss of immune neuroplasticity in ancestors and parents is believed to play a major role in onset of diseases, challenging the concept that genetics alone is origin of diseases. Deep understanding of immune neuroplasticity could lead to accurate risk assessment tools/formula, universal safe vaccines, and strategies to reduce environment-gene-immune interactions, toward preventing diseases and fostering a healthier society.