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September 10, 2025Addiction BiologyOpen Access

Selective Effects of Acutely Administered N‐Acetyl‐Cysteine in Rodent Models of Nicotine‐Conditioned Behaviours

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Authors

KSKelsey StoddartMDMichael DaviesJOJamie B. Oughton

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Overview

N-Acetyl-Cysteine shows selective attenuation of conditioned responses in nicotine-exposed rodents, suggesting limited efficacy in modifying nicotine effects.

Key Points

  • N-Acetyl-Cysteine administration attenuated conditioned hyperactivity in nicotine-exposed rats.
  • Pre-treatment doses above 20 mg/kg showed moderate effects on locomotor activity in nicotine models.
  • N-Acetyl-Cysteine did not modify nicotine's discriminative stimulus effects in the two-lever task.
  • Modest impact on hyperactivity suggests limitations in using N-Acetyl-Cysteine to manage nicotine dependence in humans.

Cite This Study

Stoddart et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7e354b1d3bfb60f9c01https://doi.org/10.1111/adb.70051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  5. 5The effects of N-acetyl cysteine on intrinsic functional connectivity and neural alcohol cue reactivity in treatment-seeking individuals with alcohol use disorder: a preliminary study2024 · 3 citations