Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Briefings in BioinformaticsOpen Access

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers

View Full Paper
Ask AI
Bookmark
Share

Authors

SWSiyue WangHLHuan LiuYYYanbo Yang

Discussion

Loading...

Member takes

Overview

Genome-wide analysis reveals extensive genomic correlations in obesity-related cancers and adiposity, suggesting shared genetic architecture.

Key Points

  • Extensive genomic correlations between adiposity measures and obesity-related cancers were identified, indicating shared genetic determinants.
  • Pleiotropic analysis revealed 464 loci and 409 genes related to both adiposity and obesity-related cancers, highlighting their interconnected nature.
  • Mendelian randomization found stronger links between genetically increased body mass index and obesity-related cancers than with other fat distributions.
  • Potential biological mechanisms include pathways related to brain-derived neurotrophic factor signaling, adipogenesis, and WNT/β-catenin signaling.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa06ahttps://doi.org/10.1093/bib/bbaf439
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics2014 · 4,812 citations
  2. 2Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots2022 · 167 citations
  3. 3Neurotrophin signalling in health and disease2006 · 637 citations
  4. 4Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications2019 · 368 citations
  5. 55-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation2020 · 354 citations