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September 28, 2025JNCI Journal of the National Cancer InstituteOpen Access

Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis

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Authors

EHEmma HazelwoodLGLucy J. GoudswaardMLMatthew A. Lee

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Overview

Mendelian randomization reveals links between adiposity types and cancer risk, suggesting tissue distribution matters for prevention.

Key Points

  • Higher genetically predicted subcutaneous adipose tissue increases the risks of endometrial, liver, and esophageal cancers significantly.
  • Genetic analysis across multiple GWAS revealed that increased visceral adipose tissue raised liver cancer risk substantially.
  • Higher gluteofemoral fat was associated with decreased risks of breast cancer and meningioma, indicating a protective role.
  • Findings suggest maintaining healthy adipose tissue distribution is important alongside weight management for cancer prevention.

Cite This Study

Hazelwood et al. (2025) studied this question.

synapsesocial.com/papers/68d913ab4ddcf71ba560bc8fhttps://doi.org/10.1093/jnci/djaf201
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating the shared genetic architecture between adiposity measures and obesity-related cancers2025 · 2 citations
  2. 2Relationships between body fat distribution and metabolic syndrome traits and outcomes: a Mendelian Randomization study2023 · 1 citations
  3. 3Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk2025 · 1 citations
  4. 4Abstract 3434: Effect modification by levels of sex hormones in the association between adiposity and cancer incidence in the UK Biobank2024
  5. 5Abstract 3632: Adiposity and cancer: Updated meta-analysis incorporating the largest evidence base to date2026