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September 10, 2025Critical Reviews in ToxicologyOpen Access

Meta-analysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning

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Authors

BCBei CaiXYXian YuXXXiaoyan Xian

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Overview

Meta-analysis shows fresh frozen plasma may lower case fatality and improve cholinesterase recovery in OP patients.

Key Points

  • FFP combination therapy reduced case fatality rates in organophosphate poisoning patients compared to conventional therapy.
  • The analysis of seven randomized clinical trials revealed a significant decrease in mechanical ventilation utilization with FFP treatment.
  • Cholinesterase recovery levels showed improvement with fresh frozen plasma therapy, showcasing its potential benefits in detoxification.
  • Despite positive findings, longer hospitalization duration and ICU length were not significantly different between groups in the analysis.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa0d2https://doi.org/10.1080/10408444.2025.2540432
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fresh frozen plasma as an adjunctive therapy in acute organophosphate poisoning: a systematic review and meta-analysis2026
  2. 2Clinical efficacy of the atropine and pralidoxime treatment combined with hemoperfusion in patients with acute organophosphate pesticide poisoning2025
  3. 3Life-Saving Resin: Hemoperfusion's Role in Overcoming Acute Organophosphate and Carbamate Poisoning2024
  4. 4Advances in the Detection and Management of Organophosphate Poisoning2025 · 2 citations
  5. 5A Comprehensive Physiotherapy Approach to Regain Functional Independence in Intermediate Syndrome Secondary to Organophosphate Poisoning: A Case Report2024 · 1 citations