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September 10, 2025Archiv EuromedicaOpen Access

Electroconvulsive Therapy as an Augmentation Strategy in Clozapine-Resistant Schizophrenia

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ECT augmentation improves positive symptoms in clozapine-resistant schizophrenia, enhancing overall clinical outcomes.
Reported adverse effects from ECT, such as headache and cognitive impairment, are typically mild and transient.
Maintenance ECT appears beneficial in sustaining remission and reducing relapse risk for this population.
Limited high-quality evidence due to small sample sizes and methodological variability constrains ECT's routine implementation.

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Narrative review evaluates electroconvulsive therapy effectiveness in clozapine-resistant schizophrenia, suggesting clinical benefits.

Zagajewska et al. (2025) studied this question.

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