What does this research mean for the field?

Electroconvulsive therapy (ECT) significantly increases clinical response in patients with clozapine-resistant schizophrenia compared to control, but the evidence is driven by a single large-effect study without sham-ECT. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Evaluate the efficacy and safety of electroconvulsive therapy (ECT) as an adjunctive treatment for clozapine-resistant schizophrenia (CRS).

March 5, 2026Journal of Ect

Electroconvulsive Therapy as an Adjunctive Treatment for Clozapine-Resistant Schizophrenia

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Evaluate the efficacy and safety of electroconvulsive therapy (ECT) as an adjunctive treatment for clozapine-resistant schizophrenia (CRS).
Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs)
Included three RCTs with 102 participants
Assessed clinical response defined by 40-50% reduction in positive psychotic symptoms and various secondary outcomes
ECT significantly increased clinical response compared to control for the primary outcome (RR = 5.63)
No difference observed at the ≥20% reduction threshold (RR = 1.96)
ECT was well tolerated with a low dropout rate

Discussion

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Implication

Meta-analysis assesses ECT's efficacy in improving symptoms of clozapine-resistant schizophrenia, suggesting careful consideration.

Cite This Study

Barros et al. (2026) studied this question.

synapsesocial.com/papers/69a91e12d6127c7a504c1a1d https://doi.org/10.1097/yct.0000000000001237

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Electroconvulsive Therapy as an Adjunctive Treatment for Clozapine-Resistant Schizophrenia

Key Points

Discussion

Implication

Cite This Study

Electroconvulsive Therapy as an Adjunctive Treatment for Clozapine-Resistant Schizophrenia

Key Points

Discussion

Implication

Cite This Study

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