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September 10, 2025Chemistry & Biodiversity

LC–ESI–MS/MS Profiling and In Vitro Evaluation of Antioxidant, Enzymatic Inhibitory, and Cytotoxic Activities, Along With Complementary In Vitro and In Silico Assessment of the Antibacterial Potential of Centaurea papposa Leaf Extracts

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Authors

JBJihane BounaasUniversity of SkikdaABAbdelkader BasliUniversity of SkikdaIOIsmahan OunissiUniversity of Skikda

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Overview

In vitro assessment reveals potential antioxidant and antibacterial effects of centaurea papposa extracts, suggesting therapeutic applications.

Key Points

  • The ethyl acetate fraction of centaurea papposa showed significant cytotoxic activity against cancer cells with an IC50 below 40 µg/mL.
  • Molecular docking analysis indicated that salicylic acid has strong interactions in the target enzyme's active site with a docking score of −6.901 kcal/mol.
  • The chloroform fraction demonstrated antibacterial activity against multiple bacteria, including Staphylococcus aureus and Escherichia coli with an MIC of 62.5 µg/mL.
  • The study identified key phenolic compounds like shikimic acid and chlorogenic acid through LC‐MS/MS analysis from centaurea papposa leaf extracts.

Cite This Study

Bounaas et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa2edhttps://doi.org/10.1002/cbdv.202501232
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