What does this research mean for the field?

Pseudocedrela kotschyi leaves and stem bark extracts contain abundant bioactive compounds, such as procyanidins and flavonoids, which exhibit significant antioxidant, enzyme inhibitory, and broad-spectrum antimicrobial activities. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the phenolic profiles, antioxidant potential, enzyme inhibitory activities, and antimicrobial actions of leaf and stem bark extracts of Pseudocedrela kotschyi prepared with methanol and water.

October 2, 2021AntioxidantsOpen Access

LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds

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Authors

KSKouadio Ibrahime Sinan SDStefano Dall’Acqua IFIrene Ferrarese

Discussion

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Overview

In vitro study reveals potent antioxidant, antimicrobial, and enzyme inhibitory properties in Pseudocedrela kotschyi extracts, highlighting their therapeutic potential.

Key Points

To evaluate the phenolic profiles, antioxidant potential, enzyme inhibitory activities, and antimicrobial actions of leaf and stem bark extracts of Pseudocedrela kotschyi prepared with methanol and water.
Extracted leaves and stem bark of Pseudocedrela kotschyi using methanol and water as solvents.
Identified and quantified bioactive phytochemicals using two distinct LC-DAD-MSn methods.
Tested extracts across multiple antioxidant assays, enzyme inhibition models (AChE, BChE, tyrosinase, α-glucosidase, α-amylase, elastase), and antimicrobial panels against various fungal and bacterial strains.
Methanol stem bark extract yielded the highest total phenolics (131.83 ± 1.81 mg GAE/g) and flavanols (14.14 ± 0.11 mg CE/g), showing superior antioxidant activity across DPPH (1.94 ± 0.01 mmol TE/g) and ABTS (3.31 ± 0.01 mmol TE/g) assays.
Methanol stem bark extracts demonstrated the greatest inhibition of acetylcholinesterase (2.54 mg GALAE/g) and butyrylcholinesterase (5.48 mg GALAE/g), whereas leaf extracts most effectively inhibited tyrosinase (77.39 ± 0.21 mg KAE/g) and α-glucosidase (0.97 ± 0.01 mmol ACAE/g).
All extracts exhibited broad antifungal activity against species including A. ochraceus and T. viride, alongside antibacterial efficacy against human pathogens including S. aureus and E. coli.

Cite This Study

Sinan et al. (2021) studied this question.

synapsesocial.com/papers/6aa95b77398b99bbe68cc5f5 https://doi.org/10.3390/antiox10101570

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October 2, 2021AntioxidantsOpen Access

LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds

View Full Paper

Ask AI

Bookmark

Authors

KSKouadio Ibrahime Sinan SDStefano Dall’Acqua IFIrene Ferrarese

Discussion

Member takes

Overview

In vitro study reveals potent antioxidant, antimicrobial, and enzyme inhibitory properties in Pseudocedrela kotschyi extracts, highlighting their therapeutic potential.

Key Points

To evaluate the phenolic profiles, antioxidant potential, enzyme inhibitory activities, and antimicrobial actions of leaf and stem bark extracts of Pseudocedrela kotschyi prepared with methanol and water.
Extracted leaves and stem bark of Pseudocedrela kotschyi using methanol and water as solvents.
Identified and quantified bioactive phytochemicals using two distinct LC-DAD-MSn methods.
Tested extracts across multiple antioxidant assays, enzyme inhibition models (AChE, BChE, tyrosinase, α-glucosidase, α-amylase, elastase), and antimicrobial panels against various fungal and bacterial strains.
Methanol stem bark extract yielded the highest total phenolics (131.83 ± 1.81 mg GAE/g) and flavanols (14.14 ± 0.11 mg CE/g), showing superior antioxidant activity across DPPH (1.94 ± 0.01 mmol TE/g) and ABTS (3.31 ± 0.01 mmol TE/g) assays.
Methanol stem bark extracts demonstrated the greatest inhibition of acetylcholinesterase (2.54 mg GALAE/g) and butyrylcholinesterase (5.48 mg GALAE/g), whereas leaf extracts most effectively inhibited tyrosinase (77.39 ± 0.21 mg KAE/g) and α-glucosidase (0.97 ± 0.01 mmol ACAE/g).
All extracts exhibited broad antifungal activity against species including A. ochraceus and T. viride, alongside antibacterial efficacy against human pathogens including S. aureus and E. coli.

Cite This Study

Sinan et al. (2021) studied this question.

synapsesocial.com/papers/6aa95b77398b99bbe68cc5f5 https://doi.org/10.3390/antiox10101570

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