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November 15, 2025Chemistry & Biodiversity

Comparative LC–MS Analysis and In Vitro Evaluation of Antioxidant, Antimicrobial, and Enzyme Inhibitory Properties of Ultrasound‐Assisted and Soxhlet Extracts of Cachrys cristata DC.

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Authors

KMKsenija S. MileskiAĆAna D. ĆirićLŽLazar D. Žarković

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Overview

In vitro evaluation reveals ultrasound-assisted extracts' strong bioactivity, inhibiting multiple bacteria and pathways.

Key Points

  • The research aims to assess the extraction methods and bioactivity of Cachrys cristata extracts.
  • Compared ultrasound-assisted and Soxhlet extraction efficiencies.
  • Analyzed phenolic composition via LC–MS profiling.
  • Tested antioxidant activity using DPPH and ABTS assays.
  • Evaluated antibacterial effects against several pathogens.
  • Assessed antidiabetic potential through α-amylase and α-glucosidase inhibition.
  • Ultrasound-assisted extraction yielded higher phenolic content than Soxhlet extraction.
  • Gentisic acid and ferulic acid were identified as dominant compounds in extracts.
  • Strong antibacterial activity observed against Staphylococcus aureus and Pseudomonas aeruginosa.
  • US methylene chloride extract inhibited α-amylase more effectively than acarbose.

Cite This Study

Mileski et al. (2025) studied this question.

synapsesocial.com/papers/6925198ec0ce034ddc353605https://doi.org/10.1002/cbdv.202501910
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