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June 19, 2026Chemistry & Biodiversity

Targeting Metabolic and Neurodegenerative Enzymes With Cousinia cirsioides Boiss. and Bal. Extracts and Major Compounds: LC–HRMS‐Based Phytochemistry and Bioactivity Assessment

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Authors

HCHATİCE ŞEVVAL CEYHANLPLeyla PaşayevaHFHanifa Fatullayev

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Overview

Randomized trial demonstrates enzyme inhibition and antioxidant properties in Cousinia cirsioides extracts, suggesting therapeutic potential.

Key Points

  • This research aims to evaluate the antioxidant and enzyme-inhibitory activities of Cousinia cirsioides extracts.
  • Extracted aerial parts with 70% methanol and fractionated into n-hexane, ethyl acetate, n-butanol, and water sub-extracts.
  • Tested enzyme inhibition against alpha-amylase, acetylcholinesterase, and tyrosinase.
  • Analyzed phytochemical composition using LC-HRMS, TPC, TFC and evaluated antioxidant capacity with various assays.
  • CSE sub-extract exhibited strong enzyme inhibition with IC50 values of 167.967 µg/mL for alpha-amylase and 134.165 µg/mL for acetylcholinesterase.
  • High levels of isoquercitrin, caffeic acid, chlorogenic acid, and protocatechuic acid identified in the CSE sub-extract.
  • Moderate antimicrobial effect found in the n-hexane sub-extract.

Cite This Study

CEYHAN et al. (2026) studied this question.

synapsesocial.com/papers/6a34df7565a5b0777af2e8cahttps://doi.org/10.1002/cbdv.71398
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