This method demonstrates the synthesis of pyranoindol-1-ones using iridium-catalyzed C─H amination of 3-amino-4-phenyl-2-pyrones, suggesting potential applications in drug development.
A method for the synthesis of multisubstituted pyranoindol‐1‐ones is developed, utilizing iridium‐catalyzed intramolecular C─H amination of 3‐amino‐4‐phenyl‐2‐pyrones synthesized via the conjugate addition of diethyl 2‐aminomalonate to alkynyl ketones. This synthetic strategy was successfully applied to the synthesis of analogues of biologically active compounds.
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Yamasaki et al. (2025) studied this question.
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