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September 10, 2025MedicineOpen Access

The effect of oral ferrous sulfate use in different posology on laboratory values and clinical findings related to iron metabolism in anemia due to iron deficiency

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Authors

MYMerve YükselAnkara UniversityMAMerve AydoğanAnkara UniversityÖDÖzlem DoğanKarolinska University Hospital

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Overview

Observational study shows significant hemoglobin improvement in iron deficiency anemia treatments, indicating optimal dosing matters.

Key Points

  • Significant increase in hemoglobin levels was observed in patients treated with different doses of oral ferrous sulfate, with notable gains at two weeks.
  • Increases in hemoglobin at the end of the third month were similar across all treatment groups, suggesting efficacy of all regimens.
  • Higher ferritin levels were detected in patients receiving 2 doses daily compared to others, emphasizing the impact of treatment frequency on iron status.
  • Gastrointestinal side effects were more prevalent in the group taking 2 doses daily, prompting a recommendation for daily or every-other-day dosing.

Cite This Study

Yüksel et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa346https://doi.org/10.1097/md.0000000000044084
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron-Deficiency Anemia2015 · 1,657 citations
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  3. 3Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization2004 · 4,846 citations
  4. 4Role of hepcidin in the pathophysiology and diagnosis of anemia2013 · 185 citations
  5. 5Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota2021 · 105 citations