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September 27, 2025Journal of Pediatric Hematology/Oncology

A Randomized Comparison Between Daily, Alternate Day and Weekly Single Dose Oral Iron Therapy in Children With Iron Deficiency Anemia

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Authors

MAMahmut AlgülFMFatih MeteBGBostan Özlem Gayret

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Overview

Randomized trial evaluated iron therapy regimens, revealing daily dose improved hemoglobin more than alternate day or weekly therapies.

Key Points

  • Hemoglobin levels increased significantly more in daily iron therapy compared to other regimens.
  • At 12 weeks, 53.3% of patients in weekly therapy continued to show anemia, compared to 26.7% with daily treatment.
  • Mean ferritin levels improved the most in children receiving daily doses of iron therapy.
  • Iron deficiency anemia remains a significant concern, necessitating effective treatment strategies.

Cite This Study

Algül et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3e9eebfec0fc5236daehttps://doi.org/10.1097/mph.0000000000003083
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Daily versus alternate day oral iron treatment for children with nutritional iron deficiency anemia2026
  2. 2Efficacy of daily versus alternate day oral iron supplementation for management of anaemia among general population: a systematic review and meta-analysis2025 · 6 citations
  3. 3Daily vs Alternate Day Iron Supplementation for Pregnant Women With Iron Deficiency Anemia: A Randomized Controlled Trial.2024 · 6 citations
  4. 4Efficacy Of Intravenous Therapy In Children With Iron Deficiency Anaemia Having Poor Response To Oral Iron Therapy2025
  5. 5The effect of oral ferrous sulfate use in different posology on laboratory values and clinical findings related to iron metabolism in anemia due to iron deficiency2025 · 2 citations