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September 10, 2025Journal of Biomaterials Science Polymer Edition

Fabrication, characterization and in vitro evaluation of PCL/PVA nanofibers loaded with docetaxel in breast cancer cells

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Authors

ZZZeynab ZamanzadeSFShohreh FahimiradMDMaryam Darvish

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Overview

In vitro assessment of docetaxel-loaded nanofibers in MCF-7 cells shows significant cytotoxicity, suggesting a potential strategy for drug delivery.

Key Points

  • DTX-loaded PCL/PVA nanofibers induced a 60% reduction in MCF-7 cell viability compared to controls.
  • Release assays showed an initial burst of ~72% DTX release within 24 hours, achieving 90% over 7 days.
  • Scanning electron microscopy confirmed smooth, bead-free morphology of the electrospun nanofibers.
  • Cytotoxicity studies indicate DTX-NFs reduced cell migration by 45% compared to free docetaxel treatment.

Cite This Study

Zamanzade et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7fe54b1d3bfb60fa486https://doi.org/10.1080/09205063.2025.2551922
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Minimizing Cytotoxic Effects on Normal Cells: Enhanced Targeted Delivery of Docetaxel via PCL-PEG-PCL Nanocarriers in Breast Cancer Treatment2025
  2. 2Chitosan Nanoparticles of Paclitaxel for the Treatment against MDA-MB-231 Breast Cancer Cells via Oral Nanomedicine: Fabrication and Preclinical Assessment2026
  3. 3Enhanced cytotoxicity of docetaxel delivered through folic acid grafted poloxamer P188 polymeric micelles2024
  4. 4Biodegradable PCL–PLGA Electrospun Nanofibers for Localized Cancer Therapy2026
  5. 5Deguelin and Paclitaxel Loaded PEG-PCL Nano-Micelles for Suppressing the Proliferation and Inducing Apoptosis of Breast Cancer Cells2024 · 7 citations