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September 10, 2025Open Access

Membrane potential modulates ERK activity and cell proliferation

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Authors

MSMari SasakiMNM. NakaharaTHT. Hashiguchi

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Overview

Experimental findings show membrane potential regulates ERK activity and boosts cell proliferation.

Key Points

  • Membrane depolarization significantly increases cell mitosis, indicating a direct link to cell growth.
  • ERK activity is modulated by membrane potential, independent of external growth factors or calcium entry.
  • Small variations in resting membrane potential can significantly impact cell proliferation activities.
  • The study identifies phosphatidylserine dynamics as central to the voltage-dependent regulation of ERK.

Cite This Study

Sasaki et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7fe54b1d3bfb60fa609https://doi.org/10.7554/elife.101613.2
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  1. 1Membrane potential modulates ERK activity and cell proliferation2025
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