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October 18, 2025Open Access

Membrane potential modulates ERK activity and cell proliferation

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Authors

MSMari SasakiMNM. NakaharaTHT. Hashiguchi

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Overview

Experimental evidence shows that membrane depolarization increases mitosis via ERK activation, highlighting membrane potential's role.

Key Points

  • Membrane depolarization significantly promotes cell proliferation by enhancing ERK activity.
  • Increased ERK activity is directly related to membrane potential changes, independent of growth factors.
  • Voltage-dependent dynamics of phosphatidylserine contribute to the observed ERK activity in cells.
  • These findings suggest broader physiological roles of membrane potentials in regulating biological processes.

Cite This Study

Sasaki et al. (2025) studied this question.

synapsesocial.com/papers/68f396388da44caaba02c92bhttps://doi.org/10.7554/elife.101613.3
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