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September 10, 2025PLoS ONEOpen Access

Age-specific benefits of Vitamin D and its association with mortality

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Authors

YWYan WangXZXueqin ZhangXWXu Wang

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Overview

Observational analysis reveals lower mortality associated with higher vitamin D levels across age groups, indicating a potential health benefit.

Key Points

  • Higher 25-hydroxyvitamin D levels are linked to a lower risk of mortality, particularly in adults aged 40-59.
  • The hazard ratio for mortality risk decreased significantly to 0.64 for those with sufficient vitamin D levels.
  • The analysis suggests optimal vitamin D levels for various age groups, with benefits most evident in older adults.
  • These findings support the potential importance of vitamin D supplementation, especially for those aged 40-59.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7fe54b1d3bfb60fa721https://doi.org/10.1371/journal.pone.0330959
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association Among Vitamin D Supplementation, Serum 25(OH)D Concentrations, and Mortality Risk: A Prospective Cohort Study Using NHANES 2007–2018 Data2024
  2. 2Association between serum 25-hydroxyvitamin D and vitamin D dietary supplementation and risk of all-cause and cardiovascular mortality among adults with hypertension2024 · 16 citations
  3. 3Plasma 25-hydroxyvitamin D concentrations, vitamin D deficiency, and mortality in community-dwelling Japanese adults2025
  4. 4Serum 25-hydroxyvitamin D concentrations and their impact on all-cause mortality in Parkinson’s disease: insights from National Health and Nutrition Examination Survey 1999–2020 data2024 · 5 citations
  5. 5Saturation association between serum 25-hydroxyvitamin D levels and mortality in elderly people with hyperlipidemia: a population-based study from the NHANES (2001-2016)2024 · 5 citations