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September 10, 2025Current Opinion in ImmunologyOpen Access

Roles of endothelial cells during infection

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Authors

ZMZhiqiang MaRPRichard W. PierceCLC. Lucas

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Overview

This review discusses the roles of endothelial cells in infection, highlighting their immune and vascular functions.

Key Points

  • Endothelial cells play a crucial role in both acute and chronic infection, impacting inflammation and organ dysfunction.
  • Pathologies caused by endothelial cell dysfunction include hypoxia and capillary barrier breakdown, which lead to septic shock.
  • The review emphasizes therapeutic implications of targeting endothelial cell functions to improve infection outcomes.
  • Emerging evidence shows that disrupted endothelial function can contribute to chronic vascular conditions and malformations.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7fe54b1d3bfb60fa72ahttps://doi.org/10.1016/j.coi.2025.102648
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