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September 10, 2025Endocrine ConnectionsOpen Access

Longitudinal analysis of serum alpha-fetoprotein in stable and progressive metastatic pancreatic neuroendocrine tumours

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Authors

JMJan MusiałkiewiczMRMarek RuchałaPKPaweł Komarnicki

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Overview

Longitudinal analysis evaluates alpha-fetoprotein's role as a diagnostic biomarker in pancreatic neuroendocrine tumours, highlighting its association with disease progression.

Key Points

  • Elevated alpha-fetoprotein levels are associated with more aggressive forms of pancreatic neuroendocrine tumours, indicating potential use in monitoring disease.
  • Significant increases in alpha-fetoprotein were correlated with higher liver tumour burdens and aggressive tumour grades, providing crucial prognostic information.
  • Serum alpha-fetoprotein concentrations were examined over four years in 41 patients, revealing a consistent upward trend linked to disease progression.
  • Findings suggest that serum alpha-fetoprotein may serve as a valuable prognostic biomarker, emphasizing the need for further prospective studies.

Cite This Study

Musiałkiewicz et al. (2025) studied this question.

synapsesocial.com/papers/68c1d80554b1d3bfb60faa58https://doi.org/10.1530/ec-25-0350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alpha-Fetoprotein-producing Neuroendocrine Carcinoma of the Pancreas with Multiple Liver Metastasis: A Case Report2026
  2. 2A Case Report of Alpha-Fetoprotein-Producing Pancreatic Neuroendocrine Tumor and Review of the Literature2025
  3. 3Serum β-hCG as a Biomarker in Pancreatic Neuroendocrine Tumors: Rethinking Single-Analyte Approach2024 · 6 citations
  4. 4An Interesting Case of Alpha-Fetoprotein (AFP)-Producing Pancreaticoduodenal Tumor2024 · 1 citations
  5. 5Predictors of long-term survival for patients with pancreatic neuroendocrine neoplasm in FinPanNET: nationwide biobank study with histopathological re-evaluation2025