A Case Report of Alpha-Fetoprotein-Producing Pancreatic Neuroendocrine Tumor and Review of the Literature

This report describes a 63-year-old woman diagnosed with an alpha-fetoprotein (AFP)-producing pancreatic neuroendocrine tumor (NET) that exhibited rapid progression and liver metastasis. Although AFP is associated with hepatocellular carcinoma and germ cell tumors, its production in NETs is unusual. Despite limited literature on AFP-producing NETs, our review indicates that such tumors are more common than previously recognized. Further studies are necessary to fully elucidate the prognostic impact and molecular mechanisms underlying AFP production in NETs.