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September 10, 2025MedCommOpen Access

Global Lactylome Reveals Lactylation‐Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome

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Authors

XLXu LiuZhongda Hospital Southeast UniversityHWHaofei WangHebei Medical UniversityWNWei‐Jie NiZhongda Hospital Southeast University

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Overview

Observational analysis shows lactate's role in PEC dysfunction in ARDS, indicating new therapeutic targets.

Key Points

  • Lactate levels in ARDS patients correlate with disease severity, impacting the prognosis of the condition.
  • Hyperlactylation at K193 of Enolase 1 was identified as enhancing CXC motif chemokine ligand 12 production.
  • The mechanism reveals how lactate-induced lactylation drives PEC dysfunction through metabolic reprogramming.
  • This study highlights lactylation as a potential therapeutic target for managing acute respiratory distress syndrome.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1d97d54b1d3bfb60fb173https://doi.org/10.1002/mco2.70344
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