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September 10, 2025Open Access

Effects of 4-Month Methylphenidate Treatment on Functional Connectivity in Attention-Deficit Hyperactivity Disorder

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Authors

EVEline VansinaLDLinda DouwAKAntonia Kaiser

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Overview

Randomized trial shows that methylphenidate enhances brain connectivity in adults with ADHD, suggesting lasting effects.

Key Points

  • Methylphenidate treatment improved whole-brain efficiency and connectivity strength in adults with ADHD.
  • Sustained increases were significant with p=0.01 for whole-brain efficiency and p=0.03 for DMN connectivity.
  • Children's cognitive performance declined with methylphenidate; placebo-treated children showed improvement.
  • Results indicate that methylphenidate enhances functional connectivity without neurobiological tolerance.

Cite This Study

Vansina et al. (2025) studied this question.

synapsesocial.com/papers/68c1d98554b1d3bfb60fb4b0https://doi.org/10.1101/2025.08.27.25334547
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electroencephalography Functional Networks Reveal Global Effects of Methylphenidate in Youth with Attention Deficit/Hyperactivity Disorder2019 · 5 citations
  2. 2Neural markers of methylphenidate response in children with attention deficit hyperactivity disorder and the impact on executive function2024
  3. 3Functional near-infrared spectroscopy study on inhibitory control ability of children with attention deficit hyperactivity disorder with methylphenidate therapy: An experimental, longitudinal, and neuroimaging study2024
  4. 4Effects of Methylphenidate on Somatic Symptoms and Brain Functional Connectivity in Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study2022 · 6 citations
  5. 5An Exploratory Study of Functional Outcome in Stimulant Treatment of ADHD in Adults2026