Key result
Six-month methylphenidate is linked to improved somatic symptoms and brain connectivity in male ADHD adolescents.
Why the study?
To evaluate whether somatic symptoms in adolescents with ADHD are associated with default mode network functional connectivity, and whether methylphenidate improves symptoms and alters connectivity.
Does methylphenidate improve somatic symptoms and alter brain functional connectivity in adolescents with ADHD?
Comparison
6 months of methylphenidate treatment in patients with vs without somatic symptoms
Design
Pilot study
Follow-up
6 months
Authors
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May support somatic symptom relief in male adolescent ADHD; hypothesis-generating for default mode network connectivity changes, needing RCTs.
Cohort (n=30)
Open-label
No
Does methylphenidate improve somatic symptoms and alter brain functional connectivity in adolescents with ADHD?
Absolute Event Rate: 27.8% vs 6.4%
p-value: p=<0.01
Methylphenidate treatment in adolescents with ADHD improves somatic symptoms and increases functional connectivity between the anterior and posterior default mode network.
Kim et al. (2022) conducted a cohort in Attention Deficit Hyperactivity Disorder (ADHD) (n=30). Methylphenidate vs. ADHD without somatic symptoms was evaluated on Change in somatic symptoms (SCL-90R-SOM score) (p=<0.01). Methylphenidate treatment for 6 months significantly improved somatic symptoms and increased brain functional connectivity within the default mode network in male adolescents with ADHD.
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