Merkel Carcinoma and Advanced Synchronous Ovarian Cancer, A Rare Presentation: Case Report and Literature Review

Objective: To report a rare case of synchronicity, Merkel carcinoma, and high-grade ovarian cancer (EC IV). We reviewed the literature and determined the clinical and pathological characteristics and treatment. Case presentation: A 62-year-old female patient with a 1-month history of disease characterized by a rapidly growing axillary tumor. The tumor was biopsied with the result: neuroendocrine carcinoma compatible with Merkel carcinoma. During the extension imaging studies, tumor lesions were identified in both ovaries. A diagnostic laparoscopy was performed, revealing evidence of multiple implants in the omentum, ovaries, and mesogenital tract. The biopsy and report were: primary high-grade serous carcinoma of the ovary. She underwent surgery at another institution for a right axillary tumor, which was reported as Merkel carcinoma, with clear margins, a tumor size of 14 cm, and subsequently received chemotherapy with subsequent interval cytoreduction and a report of complete pathological response. Currently undergoing follow-up. Conclusions: Synchronicity between Merkel carcinoma and metastatic serous ovarian carcinoma is extremely rare. Cases of metastasis of Merkel carcinoma to the ovary have been reported in only 02 cases, but the presence of both malignant neoplasms synchronously has not been reported in Latin America. Despite the concurrence of both neoplasms and the reserved prognosis, surgical and systemic treatment has allowed control of both neoplasms and after 8 months of follow-up, no local or distant recurrence is evident.