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September 10, 2025Bioscience Biotechnology Research Communications

In silico Evaluation of Plant-Derived Compounds as Potential α-Amylase Inhibitors for Treatment of Type 2 Diabetes

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Authors

DKDilip Kothari

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Overview

Molecular docking reveals potent phytochemicals in type 2 diabetes treatment, suggesting new alternatives.

Key Points

  • Top-ranked phytochemical compounds demonstrated binding affinities ranging from -11.7 to -18.6 kcal/mol, surpassing Acarbose.
  • Momordicoside R specifically targets TYR151, spotlighted as the most effective natural α-amylase inhibitor identified.
  • Molecular docking analysis involved 3,320 phytochemicals, highlighting the efficacy of compounds from both Momordica charantia and Azadirachta indica.
  • Results imply phytochemicals could serve as safer alternatives to synthetic drugs, although some face bioavailability challenges.

Cite This Study

Dilip Kothari (2025) studied this question.

synapsesocial.com/papers/68c1d98f54b1d3bfb60fb822https://doi.org/10.21786/bbrc/18.2.8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Screening In Silico Alpha-amylase and Alpha-glucosidase Inhibitory Activity of Flavonoid Compounds for the Treatment of Type 2 Diabetes2024 · 1 citations
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  3. 3In-silico approaches of Abrus precatorius compounds as potential drug inhibitors against alpha-amylase protein (4gqr).2024
  4. 4In Silico Evaluation of Anthraquinone Derivatives as Potential α-amylase and α-glucosidase Inhibitors in Diabetes Mellitus2025 · 1 citations
  5. 5Computational Screening of Phytochemicals from Trigonella foenum-graecum as Potential Inhibitor of Alpha-Amylase and Maltase-Glucoamylase in Treatment of Type 2 Diabetes2024