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September 10, 2025Open Access

Quality-By-Design (QBD) Approach in Developing a Thermoresponsive In-Situ Nasal Gel Containing Nanosized Antiviral

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Authors

SPSuneel PrajapatiIndian Institute of Technology RoparVYVaibhav YadavUnited States Nuclear Regulatory CommissionRJRahul Johari

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Implication

Optimization of a thermoresponsive nasal gel using quality-by-design and response surface methodology shows significant improvements in drug delivery and formulation stability.

Key Points

  • The optimized formulation achieved a gelling temperature in the physiological range, enhancing patient comfort and usability.
  • Results indicated sustained drug release and enhanced bioavailability, positioning it as a viable option for clinical applications.
  • Response surface methodology revealed significant interactions among formulation variables affecting gel properties.
  • ANOVA analysis confirmed model stability with R² values over 0.95, indicating a strong predictive capability of the formulation process.

Cite This Study

Prajapati et al. (2025) studied this question.

synapsesocial.com/papers/68c1d98f54b1d3bfb60fb911https://doi.org/10.64063/3049-1681.vol.2.issue8.9
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