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October 23, 2025GelsOpen Access

Investigation of Rheological Characteristics of Thermosensitive Nasal In Situ Gels Based on P407 and Their Effect on Spray Pattern

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Authors

NMNatalia MenshutinaD. Mendeleyev University of Chemical Technology of RussiaVDV. D. DerkachD. Mendeleyev University of Chemical Technology of RussiaEMElizaveta MokhovaD. Mendeleyev University of Chemical Technology of Russia

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Implication

Analytical studies demonstrate that viscosity affects spray angles in thermosensitive nasal gels, implying potential for improved drug delivery systems.

Key Points

  • Viscosity is inversely related to the spray angle in formulations, demonstrating significant implications for drug delivery systems.
  • Addition of mucoadhesive polymers like chitosan and sodium alginate significantly alters viscosity, impacting spray performance.
  • Mathematical modeling was utilized to predict spray angles based on formulation composition, showcasing a practical approach for design.
  • Results indicate that optimizing rheological characteristics could enhance therapeutic effectiveness while reducing experimental costs.

Cite This Study

Menshutina et al. (2025) studied this question.

synapsesocial.com/papers/68fa1210f9f8b44535bfcdaehttps://doi.org/10.3390/gels11100841
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In situ gel forming systems of poloxamer 407 and hydroxypropyl cellulose or hydroxypropyl methyl cellulose mixtures for controlled delivery of vancomycin2008 · 65 citations
  2. 2In situ Intranasal Delivery Systems: Application Prospects and Main Pharmaceutical Aspects of Development (Review)2021 · 18 citations
  3. 3Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy2024 · 23 citations