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September 10, 2025Open Access

Design and Characterization of Chitosan-Based Mucoadhesive Nanoparticles for Buccal Delivery of Antidiabetic Drugs

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Optimization of mucoadhesive nanoparticles improves drug release and bioavailability for diabetes treatment.

The optimized chitosan-based nanoparticles showed a 12-hour drug release profile, improving treatment efficacy.
Ex vivo buccal permeation measured a flux of 4.7 ug/cm2/h, suggesting effective absorption for antidiabetic drugs.
Formulation was refined using response-surface methodology, leading to desirable nanoparticle size and stability.
The system may enhance patient compliance and potentially avoid first-pass metabolism, improving therapeutic outcomes.

Kamble et al. (2025) studied this question.

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