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Background: Drug delivery mucoadhesion has been a subject of study for decades, initially focusing on understanding processes and investigating polymers.Mucoadhesive tablets are oral dosage forms that adhere to mucosal surfaces, promoting prolonged contact and localized drug delivery.Aim and Objective: A mucoadhesive tablet formulation of metformin could enhance drug delivery and improve therapeutic outcomes for patients with type 2 diabetes.Material and Method: The wet granulation process is used to develop mucoadhesive tablets by developing granules with the ideal characteristics for compression and tablet production.The process involves the use of natural mucoadhesive polymers like pectin and xanthan gum, along with the active component of metformin.Various testing techniques, such as weight variation, friability, hardness, DSC, TGA, XRD, in vitro dissolution, and release kinetics, are used to evaluate mucoadhesive tablets.Result and Discussion: Most formulations exhibited optimal test results within official limits in terms of friability, weight variation, and hardness.Thermal analysis indicated a transition within the temperature range, showed an exothermic peak in DSC analysis, and demonstrated temperature stability in thermogravimetric analysis.In vitro dissolution studies revealed exceptional drug release, reaching approximately 101% over 12 hours.The release kinetics modeling, performed through regression analysis, indicated sustained release.The n-exponent of the Korsmeyer and Peppas models suggested Fickian drug release.Conclusion: The successfully synthesized mucoadhesive tablets, formulated with natural and biocompatible mucoadhesive polymers, exhibit optimal drug release properties.They are utilized for
Mustafa et al. (Fri,) studied this question.