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September 10, 2025Dermatologic TherapyOpen Access

Efficacy and Safety of Hydroxychloroquine Combined With Doxycycline for the Treatment of Patients With Rosacea: A Randomized, Double‐Blind, Double‐Dummy Clinical Trial

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Authors

XYXin YuanLJLu JinLSLiang Sheng

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Overview

Randomized trial shows improved erythema and flushing in rosacea patients, suggesting better outcomes with combination therapy.

Key Points

  • The combination of hydroxychloroquine and doxycycline improves erythema in rosacea patients compared to doxycycline alone.
  • Clinical efficacy rates for erythema improvement reached 89.67% in the intervention group versus 68.97% in the control group.
  • This randomized controlled trial involved 73 moderate-to-severe rosacea patients over an 8-week period.
  • Both treatment regimens were well tolerated, indicating comparable safety profiles with no severe adverse effects reported.

Cite This Study

Yuan et al. (2025) studied this question.

synapsesocial.com/papers/68c1dd9254b1d3bfb60fbe39https://doi.org/10.1155/dth/6636265
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