Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Communications BiologyOpen Access

Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis

View Full Paper
Ask AI
Bookmark
Share

Authors

YTYe-Ya TanYOYangwen OuQZQiao Zuo

Discussion

Loading...

Member takes

Overview

Investigation reveals METTL3's influence on m6A modifications in myoblast fusion processes, suggesting a critical regulatory role.

Key Points

  • METTL3-mediated m6A regulation orchestrates myoblast fusion in differentiation and regeneration.
  • Distinct patterns of METTL3-regulated m6A modifications observed during myogenesis impact target transcripts.
  • Identification of Mymx and Mymk as direct targets of METTL3 highlights its significance in muscle programming.
  • Post-injury, Mettl3 expression is markedly induced, leading to substantial alterations in myogenesis pathways.

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68c1dd9254b1d3bfb60fbeddhttps://doi.org/10.1038/s42003-025-08759-5
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The fusogenic synapse at a glance2019 · 70 citations
  2. 2Making muscle: skeletal myogenesis in vivo and in vitro2017 · 859 citations
  3. 3Differentially expressed lncRNAs in SOD1 G93A mice skeletal muscle: H19, Myhas and Neat1 as potential biomarkers in amyotrophic lateral sclerosis2024 · 10 citations