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Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors

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Genetic risk for depression significantly impacts depressive symptoms in 2006, particularly in older adults.
Individuals with high genetic risk had 51-60% higher odds of depressive symptoms without negative experiences.
The study utilized time-varying effect modeling based on data from the Health and Retirement Study, showing key insights across age ranges.
Identifying genetic susceptibility alongside psychosocial factors may inform targeted preventive approaches for depression.

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Time-varying effects demonstrate genetic influences on depressive symptoms in older adults, suggesting psychosocial interactions.

Wilding et al. (2025) studied this question.

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