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September 10, 2025Molecular PsychiatryOpen Access

Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology

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Authors

ELEunji LeeSeoul National UniversityMDMilenna T. van DijkNew York Psychoanalytic Society and InstituteBKBo‐Gyeom KimSeoul National University

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Overview

Observational analysis reveals polygenic scores for depression impact offspring psychopathology, highlighting genetic factors.

Key Points

  • Increased polygenic scores for depression mediate the effects of family history on offspring psychopathology.
  • Greater PGS for depression and bipolar disorder were significantly associated with family history, estimating a combined impact of 1.39–5.87%.
  • Observational analysis utilized data from 11,875 children in the Adolescent Brain Cognitive Development study across multiple ancestries.
  • Findings support the genetic link in the intergenerational transmission of depression, indicating new avenues for early identification.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68c1955c9b7b07f3a0619127https://doi.org/10.1038/s41380-025-03221-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology2024 · 1 citations
  2. 2Combined family history and polygenic score prediction of major depressive disorder2025 · 1 citations
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  4. 4Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits2025 · 2 citations
  5. 5Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients2026