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September 10, 2025Journal of Psychopathology and Clinical Science

Polygenic scores for depression are associated with indices of neighborhood adversity.

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Authors

CFCope FeurerJMJohn E. McGearyCBChelsie E. Benca‐Bachman

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Overview

Observational analysis shows genetic liability for depression relates to neighborhood adversity in youth, suggesting environmental stressors play a role.

Key Points

  • Children with greater genetic liability for depression lived in neighborhoods with higher adversity, highlighting environmental impacts.
  • Associations were maintained even when controlling for family socioeconomic status and histories of depression and anxiety.
  • The study involved 278 preadolescent children, emphasizing the importance of examining neighborhood influences on mental health.
  • Findings indicate that polygenic scores may capture genetic liability for stress exposure at the neighborhood level.

Cite This Study

Feurer et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4cd1https://doi.org/10.1037/abn0001038
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity2025
  2. 2Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression2024 · 11 citations
  3. 3Reviewing Genetic Insights into Depression: Exploring Polygenic Score Risk and Environmental Influences in Depression2024 · 1 citations
  4. 4Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology2025 · 4 citations
  5. 5Genetic risks for depression and educational achievement in adolescence2026