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October 3, 2025Open Access

Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity

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Authors

CFCope Feurer JMJohn E. McGeary CBChelsie E. Benca‐Bachman

Discussion

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Overview

Analysis reveals that higher depression polygenic scores correlate with greater levels of neighborhood adversity, indicating potential stress exposure implications.

Key Points

Children with higher polygenic scores for depression live in neighborhoods with greater adversity, which may increase stress exposure.
Among 278 preadolescent children studied, those with higher DEP-PGSs experienced more neighborhood-level adversity and socio-economic disadvantage.
Approach involved clinical interviews, questionnaires, and genetic sampling in assessing the relationship between DEP-PGSs and neighborhood conditions.
These findings support the concept of gene-environment correlations, suggesting that genetic propensity for depression may influence neighborhood context.

Cite This Study

Feurer et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2ed0 https://doi.org/10.31234/osf.io/65wef_v2

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October 3, 2025Open Access

Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity

View Full Paper

Ask AI

Bookmark

Authors

CFCope Feurer JMJohn E. McGeary CBChelsie E. Benca‐Bachman

Discussion

Member takes

Overview

Analysis reveals that higher depression polygenic scores correlate with greater levels of neighborhood adversity, indicating potential stress exposure implications.

Key Points

Children with higher polygenic scores for depression live in neighborhoods with greater adversity, which may increase stress exposure.
Among 278 preadolescent children studied, those with higher DEP-PGSs experienced more neighborhood-level adversity and socio-economic disadvantage.
Approach involved clinical interviews, questionnaires, and genetic sampling in assessing the relationship between DEP-PGSs and neighborhood conditions.
These findings support the concept of gene-environment correlations, suggesting that genetic propensity for depression may influence neighborhood context.

Cite This Study

Feurer et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2ed0 https://doi.org/10.31234/osf.io/65wef_v2

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