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June 14, 2026European SocietiesOpen Access

Genetic risks for depression and educational achievement in adolescence

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Authors

AHArno Van HootegemTBTina BaierJHJan Paul Heisig

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Overview

Randomized trial explores genetic effects on educational achievement in adolescents, suggesting a minimal impact from depression genetics.

Key Points

  • The study aims to understand the genetic associations between major depressive disorder and educational achievement in adolescents.
  • Analyzed nearly 38,000 parent-child trios from the Norwegian Mother and Child Cohort Study.
  • Estimated direct and indirect effects of adolescents' and parents' depression polygenic scores on educational achievement.
  • Conducted mediation analyses to assess the role of parental education and income.
  • A 1-SD increase in the child's depression PGS predicts a 0.05 SD decline in test scores (p-value not stated).
  • The association becomes non-significant when adjusting for parental depression and education polygenic scores.
  • Parental depression PGS shows small negative associations with child educational achievement.

Cite This Study

Hootegem et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4632b1cc60ccdea8afcfhttps://doi.org/10.1162/euso.a.119
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