Investigation reveals significant pKa shifts in raloxifene with different micelles, suggesting altered interactions.
The protolytic equilibria of raloxifene were investigated in the presence of differently charged and/or polar micelles (CTAB, TX-100, Brij 35). The ionization constants were determined potentiometrically at a constant ionic strength (0.1 M NaCl) and temperature 25°C. In a relation to the pKa values previously determined in surfactant-free media, the presence of micelles caused a shift from -3.03 pKa to +3.12 pKa units. Significant changes in distribution of equilibrium forms at biopharmaceutically important pH values suggest on potential consideration of interactions between raloxifene and molecules present under the physiological conditions.
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Popović-Nikolić et al. (2024) studied this question.
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