Pattern of Nitric Oxide Levels and Endothelial Nitric Oxide Synthase in Preeclamptic Women Visiting General Hospital Owerri

A condition unique to pregnancy, preeclampsia results in morbidity and mortality in both the mother and the fetus. Preeclampsia's precise etiology is unclear. However, the pathophysiology of preeclampsia is greatly influenced by endothelial dysfunction. The purpose of this study was to quantify the levels of maternal serum NO and endothelial nitric oxide synthase (eNOS) in preeclamptic women. In this study, 100 preeclamptic women and 100 normotensive women served as the control group. The conventional approach was used to assess the levels of nitric oxide and nitric oxide synthase. When comparing the levels of Nitric Oxide Synthase and Nitric Oxide in preeclampsia (4.10 ± 1.96 ng/mL and 6.11 ± 3.41 μmoles/L) to those in healthy pregnant women (7.22 ± 3.01 ng/mL and 12.52 ± 3.30 μmoles/L, respectively), at p<0.05, the differences were statistically significant. The study reveals that altered endothelial function in preeclampsia was indicated by lower endothelial Nitric Oxide Synthase and nitric oxide.