Key result
Preeclampsia was associated with significantly higher serum nitrate (15 vs 11.82 micromol/L) and nitrite (11.82 vs 5.08 micromol/L) levels compared to normotensive pregnancies (p<0.001).
Why the study?
Are serum nitrate and nitrite levels elevated in primigravidas with preeclampsia compared to normotensive pregnancies?
Case-Control (n=100)
Are serum nitrate and nitrite levels elevated in primigravidas with preeclampsia compared to normotensive pregnancies?
Absolute Event Rate: 15% vs 11.82%
p-value: p=< 0.001
Serum levels of nitric oxide oxidative products (nitrates and nitrites) are significantly elevated in preeclampsia and correlate with disease severity, suggesting a role in its pathophysiology.
May not alter preeclampsia management; hypothesis-generating for nitric oxide biomarkers in hypertensive pregnancy.
Oxidative products of nitric oxide, serum nitrates and nitrites were estimated in 50 primigravidas with preeclampsia and in 50 gestation and age-matched normotensive primigravidas. Thirty three (66%) of these women had mild preeclampsia and 17 (34%) had severe preeclampsia. Serum nitrate and nitrite levels were significantly higher in preeclamptic women (nitrates - 15 +/- 1.17; nitrites - 11.82 +/- 1.16 micromol/L) than in the normotensive pregnant women (nitrates 11.82 +/- 1.16; nitrites - 5.08 +/- 0.47 micromol/L, p < 0.001). In preeclamptic women, serum nitrate and nitrite levels correlated with the severity of the disease (mild preeclampsia nitrate - 14.46 +/- 1.98; nitrite 6.21 +/- 0.84 micromol/L, severe preeclampsia nitrate - 16.65 +/- 3.64; Nitrite - 6.87 +/- 1.56 micromol/L). In preeclampsia there was significant positive correlation between nitrate and nitrite levels and diastolic blood pressure and proteinuria.
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Pathak et al. (1999) conducted a case-control in Preeclampsia (n=100). Preeclampsia vs. Normotensive pregnancy was evaluated on Serum nitrate levels (micromol/L) (p=< 0.001). Preeclampsia was associated with significantly higher serum nitrate (15 vs 11.82 micromol/L) and nitrite (11.82 vs 5.08 micromol/L) levels compared to normotensive pregnancies (p<0.001).
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