Clinical analysis identifies age-related features of meningococcal infection, suggesting improved therapeutic approaches.
The paper presents a clinical and laboratory analysis of generalized forms of meningococcal infection (MI) in 90 patients aged 1 month to 18 years. The age-related features of the disease under the present conditions and a relationship of its clinical manifestations to the serogroup of a meningococcus are determined. The implication of endogenous intoxication, proteolysis and a systemic inflammatory reaction in the pathogenesis of MI is established. The expediency of co-administration of antibacterial drugs and systemic enzymes and prolonged infusion therapy for generalized forms of MI is scientifically founded and the efficiency of the proposed therapeutic tactics is proven.
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Скрипченко et al. (2010) studied this question.
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