September 11, 2025

Susceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older Adults.

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Prospective study links brain iron and amyloid-β levels to cognitive decline in older adults, suggesting early intervention might be beneficial.

Higher baseline magnetic susceptibility predicts greater risk of mild cognitive impairment onset and cognitive decline.
In 158 older adults, higher susceptibility levels in the entorhinal cortex were linked to MCI risk, with hazard ratios indicating significant findings.
Assessment utilized quantitative susceptibility mapping MRI and PET in a prospective manner over a follow-up period of up to 7.7 years.
These findings highlight the importance of early diagnostic markers for cognitive impairments in cognitively unimpaired individuals.

Chen et al. (2025) studied this question.

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Prospective study links brain iron and amyloid-β levels to cognitive decline in older adults, suggesting early intervention might be beneficial.