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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Increased susceptibility in the anterior hippocampal dentate gyrus and CA4 region of patients with mild cognitive impairment

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Authors

GZGaoxing ZhengHenan University of TechnologyYHYujia HuangCivil Aviation University of ChinaSMSnehal MazumderThe University of Texas Southwestern Medical Center

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Overview

Analysis shows increased susceptibility in the anterior hippocampal dentate gyrus and CA4 in MCI patients, implying potential early biomarkers for Alzheimer's disease.

Key Points

  • Increased susceptibility in the anterior hippocampal dentate gyrus and CA4 is found in patients with mild cognitive impairment.
  • Magnetic susceptibility changes were compared between 13 MCI subjects and 13 normal controls, highlighting significant differences.
  • Analysis involves manual hippocampal segmentations based on 7T quantitative susceptibility mapping, enhancing spatial resolution.
  • Findings suggest that investigating iron accumulation in hippocampal subregions could improve early detection of Alzheimer's disease.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c837https://doi.org/10.58530/2025/1796
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultra-high Resolution in vivo 7T MRI Detects Hippocampal Subfield Iron in Mild Cognitive Impairment and Alzheimer’s Disease2025
  2. 2Investigation of Iron Deposition Metabolism in Alzheimer’s Disease in Hippocampal Subregions using QSM-MRI2025
  3. 3Investigation of iron content changes in Alzheimer's disease and mild cognitive impairment using quantitative susceptibility mapping2024
  4. 4Quantitative susceptibility mapping of hippocampal iron relates to pattern separation and completion in older adults at risk for Alzheimer's2024
  5. 5Susceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older Adults.2025