Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Investigation of Iron Deposition Metabolism in Alzheimer’s Disease in Hippocampal Subregions using QSM-MRI

View Full Paper
Ask AI
Bookmark
Share

Authors

DLDongxue LiJHJunjie HeLZLin Zhu

Discussion

Loading...

Member takes

Overview

Analysis reveals reduced neuronal volume and increased iron deposition in Alzheimer's hippocampal subregions, suggesting critical insights for treatment strategies.

Key Points

  • Increased iron deposition in certain hippocampal subregions is linked to reduced neuronal volume, highlighting potential degeneration.
  • QSM and 3D T1-weighted MRI were utilized to quantify magnetic susceptibility and volume, focusing on 24 hippocampal segments.
  • The findings indicate a connection between iron accumulation and neuronal loss, providing insights into ferroptosis in Alzheimer's disease.
  • Identifying these imaging biomarkers could inform personalized treatment strategies in patients with Alzheimer’s disease.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c66bhttps://doi.org/10.58530/2025/1790
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased susceptibility in the anterior hippocampal dentate gyrus and CA4 region of patients with mild cognitive impairment2025
  2. 2Ultra-high Resolution in vivo 7T MRI Detects Hippocampal Subfield Iron in Mild Cognitive Impairment and Alzheimer’s Disease2025
  3. 3Investigation of iron content changes in Alzheimer's disease and mild cognitive impairment using quantitative susceptibility mapping2024
  4. 4Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease2024 · 11 citations
  5. 57T GRE Enables Detection of Subiculum Iron Deposits in AD2024